How to connect the USB interface when its VDDIO4 is 1.8V?

Troubleshooting
1

As per the title.

Since VDDIO4 is 1.8V, and the power domain of the USB interface is on VDDIO4.

Can the USB interface be directly connected to the USB connector, or is level shifting required in between?

2

USB does not depend on the level of VDDIO4 and can be directly connected and used.